Du må ikke benytte receptpligtige potenspiller sammen med lægemidler der indeholder nitrater. Dette skyldes, at Viagra og nitrater har lignende effekter og fileår dine muskler til at slappe af og dine blodårer til at udvide sig.
By controlling the enzyme, sildenafil will help to keep up an erection after the penis is stroked. With out Actual physical action for the penis, including that taking place through sexual intercourse, sildenafil will never perform to cause an erection.
Sure medicines should not be utilized at or round the time of eating meals or ingesting specified different types of meals due to the fact interactions may well come about.
†Irregular Eyesight: Gentle to moderate in severity and transient, predominantly coloration tinge to vision, but will also increased sensitivity to light-weight, or blurred vision.
There is a potential for cardiac danger of sexual exercise in sufferers with preexisting heart problems. As a result, treatment plans for erectile dysfunction, which includes VIAGRA, really should not be generally used in Gentlemen for whom sexual action is inadvisable thanks to their fundamental cardiovascular position.
This Affected person Details leaflet summarizes An important details about VIAGRA. If you want to more details, speak with your healthcare provider. You could request your healthcare provider or pharmacist for information regarding VIAGRA that is certainly written for wellbeing experts.
Viagra er en potenspille som inneholder den aktive ingrediensen sildenafilsitrat i 25mg, 50mg eller 100mg. Den aktive ingrediensen sildenafil er en såkalt PDE5-hemmer som blokkerer PDE5 slik at enzymet cGMP igjen får tid til å fungere.
Viagra experienced no effect on saquinavir pharmacokinetics. A more robust CYP3A4 inhibitor such as ketoconazole or itraconazole may very well be predicted to have better influence than that found with saquinavir. Inhabitants pharmacokinetic details from patients in clinical trials also indicated a discount in sildenafil clearance when it was co-administered with CYP3A4 inhibitors (including ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
The indicate steady state volume of distribution (Vss) for sildenafil is a hundred and five L, indicating distribution in the tissues. Sildenafil get more info and its major circulating N-desmethyl metabolite are the two close to 96% bound to plasma proteins. Protein binding is impartial of total drug concentrations.
Medical professionals should explore with individuals the prospective cardiac risk of sexual exercise in individuals with preexisting cardiovascular hazard variables. People who working experience signs or symptoms (e.
Single oral doses of sildenafil nearly 100 mg manufactured no clinically appropriate modifications while in the ECGs of ordinary male volunteers.
NO then activates the enzyme guanylate cyclase, which results in elevated levels of cyclic guanosine monophosphate (cGMP), developing easy muscle mass relaxation in the corpus cavernosum and permitting inflow of blood.
Sildenafil really should not be employed if sexual exercise is inadvisable resulting from underlying cardiovascular threat things.[31]
Just after possibly oral or intravenous administration, sildenafil is excreted as metabolites predominantly during the feces (close to eighty% of administered oral dose) and to a lesser extent in the urine (close to 13% of the administered oral dose).